Significant Admixture Linkage Disequilibrium across 30 cM around the FY Locus in African Americans
نویسندگان
چکیده
منابع مشابه
Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium
Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous admixture events, which is common for most existing admixed populations. Unlike p...
متن کاملEstimating the timing of multiple admixture events using 3-locus Linkage Disequilibrium
Estimating admixture histories is crucial for understanding the genetic diversity we see in present-day populations. Existing allele frequency or phylogeny-based methods are excellent for inferring the existence of admixture or its proportions, but have less power for estimating admixture times. Recently introduced approaches for estimating these times use spatial information from admixed chrom...
متن کاملLinkage Disequilibrium across the UGT1A Locus Should Not Be Ignored in Association Studies of Cancer Susceptibility
The study by Wang et al. (1) reported an association between human UGT1A7 gene polymorphisms and hepatocellular carcinoma (HCC) in Japanese patients with hepatitis C virus infection. The authors observed a significantly higher frequency of UGT1A7*1/*3 and UGT1A7*2/*3 genotypes/ diplotypes in hepatitis C virus– infected patients with HCC compared with those without HCC. This association seemed t...
متن کاملThe Pattern of Linkage Disequilibrium in Livestock Genome
Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2000
ISSN: 0002-9297
DOI: 10.1086/302820